Gellified emulsion (emulsion in gel) have emerged as one of the most interesting topical drug delivery system as it has dual release control system i.e. emulsion and gel. Also stability of emulsion is increased when it is incorporated in gel. They have a high patient acceptability since they possess the advantages of both emulsions and gels. Apart from physicochemical evaluation during development of topical preparation, it is must to check the material and method which ensures the sterility and also needful to analyze that the preservative used in the formulation is efficient. The present work is to confirm that the material and method used for preparation of ibuprofen emulgel doesn’t impart any microbial contamination and the preservative methyl paraben 0.25 % used is sufficient to prevent the microbial attack for this formulation. The preservative efficiency test and microbial contamination test were carried.
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